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PGT-M conditions

The page below lists all PGT-M conditions currently authorised and awaiting consideration by the HFEA.

When publishing genetic conditions on the authorised list, we aim to be as consistent as possible with the OMIM database. However, many conditions may have several different names and we would recommend searching the list using the OMIM number for the condition as this is less likely to change throughout time.

If a condition does not appear on the list, it does not necessarily mean the condition has specifically not been authorised, it may mean that we have never before received an application from a UK centre to perform PGT-M for this condition and it has therefore never been considered by the HFEA.

Please note that we are always processing new applications to add genetic conditions to the list from UK centres licensed to perform PGT-M. This may mean that some authorised conditions may not be displayed. If you are unsure if a condition has been authorised or not, or would like any further information please contact the PGTM team at pgtm@hfea.gov.uk.

Click here for a downloadable list: approved condition list. Please note that the website page below is updated more regularly and is therefore more accurate than the downloadable list.

Condition name Status OMIM number Documents
Methylmalonic Acidemia (MMA) approved 251000
Methylmalonic Acidemia cb1A approved 251100
Methylmalonic Acidemia cb1B approved 251110
Methylmalonic Aciduria and Homocystinuria approved 277400
Micro Syndrome (WARBM) approved 600118
Microcephalic Osteodysplastic Primordial Dwarfism Type 1, (MOPD1) approved 210710
Microcephalic Osteodysplastic Primordial Dwarfism Type 2, (MOPD2) approved 210720
Microcephaly with or without Chorioretinopathy, Lymphedema, or Impaired Intellectual Development (MCLMR) approved 152950
Microcephaly, Facial Dysmorphism, Renal Agenesis, and Ambiguous Genitalia Syndrome; MFRG approved 618142
Microcephaly, seizures, and developmental delay (MCSZ) approved 613402
Microcephaly, Short Stature and Polymicrogyria with or without seizures (MSSP) approved 614833
Microcornea, Myopic Chorioretinal Atrophy, and Telecanthus (MMCAT) approved 615458
Microhydranencephaly (MHAC) approved 605013
Microphthalmia, Isolated, with Coloboma 3 (MCOPCB3) approved 610092
Microphthalmia, Isolated, with Coloboma 8 (MCOPCB8) approved 601186
Microphthalmia, Syndromic 15 (MCOPS15) approved 615145
Microphthalmia, Syndromic 9 (MCOPS9) approved 601186
Minicore Myopathy with External Ophthalmoplegia approved 255320
Mismatch Repair Cancer Syndrome (MMRCS) approved 276300
Mismatch Repair Cancer Syndrome 2, (MMRCS2) approved 619096