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PGT-M conditions

The page below lists all PGT-M conditions currently authorised and awaiting consideration by the HFEA.

When publishing genetic conditions on the authorised list, we aim to be as consistent as possible with the OMIM database. However, many conditions may have several different names and we would recommend searching the list using the OMIM number for the condition as this is less likely to change throughout time.

If a condition does not appear on the list, it does not necessarily mean the condition has specifically not been authorised, it may mean that we have never before received an application from a UK centre to perform PGT-M for this condition and it has therefore never been considered by the HFEA.

Please note that we are always processing new applications to add genetic conditions to the list from UK centres licensed to perform PGT-M. This may mean that some authorised conditions may not be displayed. If you are unsure if a condition has been authorised or not, or would like any further information please contact the PGTM team at pgtm@hfea.gov.uk.

Click here for a downloadable list: approved condition list. Please note that the website page below is updated more regularly and is therefore more accurate than the downloadable list.

Condition name Status OMIM number Documents
Microhydranencephaly (MHAC) approved 605013
Microphthalmia, Isolated, with Coloboma 3 (MCOPCB3) approved 610092
Microphthalmia, Isolated, with Coloboma 8 (MCOPCB8) approved 601186
Microphthalmia, Syndromic 15 (MCOPS15) approved 615145
Microphthalmia, Syndromic 9 (MCOPS9) approved 601186
Minicore Myopathy with External Ophthalmoplegia approved 255320
Mismatch Repair Cancer Syndrome (MMRCS) approved 276300
Mismatch Repair Cancer Syndrome 2, (MMRCS2) approved 619096
Mismatch Repair Cancer Syndrome 3, (MMRCS3) approved 619097
Mismatch Repair Cancer Syndrome 4, (MMRCS4) approved 619101
Mitochondrial Complex I Deficiency, Nuclear Type 1 (MC1DN1) approved 252010
Mitochondrial Complex I Deficiency, Nuclear Type 10 (MC1DN10) approved 618233
Mitochondrial Complex I Deficiency, Nuclear Type 11 (MC1DN11) approved 618234
Mitochondrial Complex I Deficiency, Nuclear type 13 (MC1DN13) approved 618235
Mitochondrial Complex I Deficiency, Nuclear Type 14 (MC1DN14) approved 618236
Mitochondrial Complex I Deficiency, Nuclear Type 15 (MC1DN15) approved 618237
Mitochondrial Complex I Deficiency, Nuclear Type 16 (MC1DN16) approved 618238
Mitochondrial Complex I Deficiency, Nuclear type 17 (MC1DN17) approved 618239
Mitochondrial Complex I Deficiency, Nuclear Type 18 (MC1DN18) approved 618240
Mitochondrial Complex I Deficiency, Nuclear Type 19 (MC1DN19) approved 618241