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PGT-M conditions

The page below lists all PGT-M conditions currently authorised and awaiting consideration by the HFEA.

When publishing genetic conditions on the authorised list, we aim to be as consistent as possible with the OMIM database. However, many conditions may have several different names and we would recommend searching the list using the OMIM number for the condition as this is less likely to change throughout time.

If a condition does not appear on the list, it does not necessarily mean the condition has specifically not been authorised, it may mean that we have never before received an application from a UK centre to perform PGT-M for this condition and it has therefore never been considered by the HFEA.

Please note that we are always processing new applications to add genetic conditions to the list from UK centres licensed to perform PGT-M. This may mean that some authorised conditions may not be displayed. If you are unsure if a condition has been authorised or not, or would like any further information please contact the PGTM team at

Click here for a downloadable list: approved condition list. Please note that the website page below is updated more regularly and is therefore more accurate than the downloadable list.

Condition name Status OMIM number Documents
Spinal Muscular Atrophy 1 (SMA1) approved 253300
Spinal Muscular Atrophy and Respiratory Distress (SMARD1) approved 604320
Spinal muscular atrophy type 2 approved 253550
Spinal muscular atrophy type 3 approved 253400
Spinal Muscular Atrophy with Congenital Bone Fractures 1 (SMABF1) approved 616866
Spinal Muscular Atrophy with Congenital Bone Fractures 2 (SMABF2) approved 616867
Spinocerebella rataxia 21 (SCA21) approved 607454
Spinocerebellar ataxia 10 (SCA10) approved 603516
Spinocerebellar ataxia 11 (SCA11) approved 604432
Spinocerebellar ataxia 12 (SCA12) approved 604326
Spinocerebellar ataxia 13 (SCA13) approved 605259
Spinocerebellar ataxia 15 (SCA15) approved 606658
Spinocerebellar ataxia 17 (SCA17) approved 607136
Spinocerebellar ataxia 19 (SCA19) approved 607346
Spinocerebellar ataxia 20 (SCA20) approved 608687
Spinocerebellar ataxia 23 (SCA23) approved 610245
Spinocerebellar ataxia 27 (SCA27) approved 609307
Spinocerebellar ataxia 28 (SCA28) approved 610246
Spinocerebellar ataxia 29 (SCA29) approved 117360
Spinocerebellar ataxia 31 (SCA31) approved 117210