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PGT-M conditions

The page below lists all PGT-M conditions currently authorised and awaiting consideration by the HFEA.

When publishing genetic conditions on the authorised list, we aim to be as consistent as possible with the OMIM database. However, many conditions may have several different names and we would recommend searching the list using the OMIM number for the condition as this is less likely to change throughout time.

If a condition does not appear on the list, it does not necessarily mean the condition has specifically not been authorised, it may mean that we have never before received an application from a UK centre to perform PGT-M for this condition and it has therefore never been considered by the HFEA.

Please note that we are always processing new applications to add genetic conditions to the list from UK centres licensed to perform PGT-M. This may mean that some authorised conditions may not be displayed. If you are unsure if a condition has been authorised or not, or would like any further information please contact the PGTM team at pgtm@hfea.gov.uk.

Click here for a downloadable list: approved condition list. Please note that the website page below is updated more regularly and is therefore more accurate than the downloadable list.

Condition name Status OMIM number Documents
Laryngo-onycho-cutaneous (LOC) Syndrome approved 245660
Laurin-Sandrow Syndrome (LSS) approved 135750
Leber congenital amaurosis (LCA) approved 204000, 204100
Leber congenital amaurosis type 10 approved 611755
Leber congenital amaurosis type 12 approved 610612
Leber congenital amaurosis type 13 approved 612712
Leber congenital amaurosis type 14 approved 613341
Leber congenital amaurosis type 15 approved 613843
Leber congenital amaurosis type 16 approved 614186
Leber congenital amaurosis type 17 approved 615360
Leber congenital amaurosis type 3 approved 604232
Leber congenital amaurosis type 4 approved 604393
Leber congenital amaurosis type 5 approved 604537
Leber congenital amaurosis type 6 approved 613826
Leber congenital amaurosis type 7 (autosomal recessive only) approved 613829
Leber congenital amaurosis type 8 approved 613835
Leber congenital amaurosis type 9 approved 608553
Leber's Hereditary Optic Neuropathy (LHON) / Lebers Optic atrophy approved 535000
Leigh Syndrome approved 256000
Leigh Syndrome (Infantile Subacute Necrotising Encephalopathy) due to COX IV deficiency approved 185620