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PGT-M conditions

The page below lists all PGT-M conditions currently authorised and awaiting consideration by the HFEA.

When publishing genetic conditions on the authorised list, we aim to be as consistent as possible with the OMIM database. However, many conditions may have several different names and we would recommend searching the list using the OMIM number for the condition as this is less likely to change throughout time.

If a condition does not appear on the list, it does not necessarily mean the condition has specifically not been authorised, it may mean that we have never before received an application from a UK centre to perform PGT-M for this condition and it has therefore never been considered by the HFEA.

Please note that we are always processing new applications to add genetic conditions to the list from UK centres licensed to perform PGT-M. This may mean that some authorised conditions may not be displayed. If you are unsure if a condition has been authorised or not, or would like any further information please contact the PGTM team at pgtm@hfea.gov.uk.

Click here for a downloadable list: approved condition list. Please note that the website page below is updated more regularly and is therefore more accurate than the downloadable list.

Condition name Status OMIM number Documents
Mucolipidosis type II approved 252500
Mucopolysaccharidosis III (MPS-III) Type A (Sanfilippo syndrome A) approved 252900
Mucopolysaccharidosis III (MPS-III) Type B approved 252920
Mucopolysaccharidosis III (MPS-III) Type C approved 252930
Mucopolysaccharidosis III (MPS-III) Type D approved 252940
Mucopolysaccharidosis IVA approved 253000
Mucopolysaccharidosis Type I (MPS I) approved 607014, 607015, 607016
Mucopolysaccharidosis Type II (Hunter Syndrome) approved 309900
Mucopolysaccharidosis Type IVB (MPS4B) approved 253010
Mucopolysaccharidosis Type VI (MPS VI) (Maroteaux-Lamy Syndrome) approved 253200
Mucopolysaccharidosis Type VII (MPS7) approved 253220
Muenke Syndrome (MNKES) approved 602849
Multiple acyl-CoA dehydrogenase deficiency (MADD) (also known as glutaric aciduria type II) approved 231680
Multiple Congenital Anomalies Hypotonia – Seizures Syndrome 1 (MCAHS1) approved 614080
Multiple Congenital Anomalies Hypotonia – Seizures Syndrome 2 (MCAHS2) approved 300868
Multiple Congenital Anomalies Hypotonia – Seizures Syndrome 3 (MCAHS3) approved 615398
Multiple Endocrine Neoplasia Type 2A (MEN 2A) approved 171400
Multiple Endocrine Neoplasia type 2B (MEN 2B) approved 162300
Multiple Endocrine Neoplasia Type I (MEN1) approved 131100
Multiple Epiphyseal Dysplasia Type 5 (MED5) approved 607078