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PGT-M conditions

The page below lists all PGT-M conditions currently authorised and awaiting consideration by the HFEA.

When publishing genetic conditions on the authorised list, we aim to be as consistent as possible with the OMIM database. However, many conditions may have several different names and we would recommend searching the list using the OMIM number for the condition as this is less likely to change throughout time.

If a condition does not appear on the list, it does not necessarily mean the condition has specifically not been authorised, it may mean that we have never before received an application from a UK centre to perform PGT-M for this condition and it has therefore never been considered by the HFEA.

Please note that we are always processing new applications to add genetic conditions to the list from UK centres licensed to perform PGT-M. This may mean that some authorised conditions may not be displayed. If you are unsure if a condition has been authorised or not, or would like any further information please contact the PGTM team at

Click here for a downloadable list: approved condition list. Please note that the website page below is updated more regularly and is therefore more accurate than the downloadable list.

Condition name Status OMIM number Documents
Primary Microcephaly 7 (MCPH7) approved 612703
Primary Microcephaly 8 (MCPH8) approved 614673
Primary Microcephaly 9 (MCPH9) approved 614852
Prion disease with protracted course approved 606688
Progressive External Opthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant 3 (PEOA3) approved 609286
Progressive Familial Intrahepatic Cholestasis Type 1 (PFIC1) approved 211600
Prolidase Deficiency approved 170100
Propionic Acidemia approved 606054
Pseudoachondroplasia approved 177170
Pseudohypoparathyroidism (PHP1a) approved 103580
Pseudo-TORCH syndrome-type 1 approved 251290
Pseudo-TORCH syndrome-type 2 approved 617397
Pseudovaginal Perineoscrotal Hypospadias due to 5-Alpha-Reductase Deficiency (insofar as that condition affects males, with simultaneous sex determination) approved 264600
Pyogenic Arthritis, Pyoderma Gangrenosum and Acne Syndrome (PAPA) approved 604416
Pyrodoxine-dependent seizures (EPD) approved 266100
Pyruvate dehydrogenase E1-alpha deficiency X-linked approved 312170
Pyruvate Dehydrogenase E1-beta Deficiency approved 614111
Pyruvate Dehydrogenase E2 Deficiency (PDHDD) approved 245348
Pyruvate Dehydrogenase E3-Binding Protein Deficiency (PDHXD) approved 245349
Pyruvate Dehydrogenase Phosphatase Deficiency (PDHPD) approved 608782