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The HFEA has launched its new data dashboard with data going back over 30 years. Access it here.

PGT-M conditions

The page below lists all PGT-M conditions currently authorised and awaiting consideration by the HFEA.

When publishing genetic conditions on the authorised list, we aim to be as consistent as possible with the OMIM database. However, many conditions may have several different names and we would recommend searching the list using the OMIM number for the condition as this is less likely to change throughout time.

If a condition does not appear on the list, it does not necessarily mean the condition has specifically not been authorised, it may mean that we have never before received an application from a UK centre to perform PGT-M for this condition and it has therefore never been considered by the HFEA.

Please note that we are always processing new applications to add genetic conditions to the list from UK centres licensed to perform PGT-M. This may mean that some authorised conditions may not be displayed. If you are unsure if a condition has been authorised or not, or would like any further information please contact the PGTM team at pgtm@hfea.gov.uk.

Click here for a downloadable list: approved condition list. Please note that the website page below is updated more regularly and is therefore more accurate than the downloadable list.

Condition name Status OMIM number Documents
Alpha-1-antitrypsin deficiency approved +107400 (where two Z alleles are inherited)
Alpha-Mannosidosis approved 248500
Alport Syndrome approved 301050
Alport Syndrome approved 203780
Alport Syndrome (Autosomal Dominant) approved 104200
Alstrom Syndrome; ALMS approved 203800
Alzheimer's Disease - early onset approved 104300
Alzheimer's Disease - early onset (Types 3 and 4) approved 607822, 606889
Amegakaryocytic Thrombocytopenia, Congenital, 1 (CAMT1) awaiting consideration 604498
Amyotrophic Lateral Sclerosis (ALS) 6 approved 608030
Amyotrophic Lateral Sclerosis 1 (ALS1) approved 105400
Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia approved 612069
Amyotrophic lateral sclerosis 11 approved 612577
Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia approved 613954
Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia approved 300857
Amyotrophic lateral sclerosis 17 approved 614696
Amyotrophic lateral sclerosis 18 approved 614808
Amyotrophic lateral sclerosis 19 approved 615515
Amyotrophic lateral sclerosis 2, juvenile approved 205100
Amyotrophic lateral sclerosis 21 approved 606070