Deafness, autosomal dominant 15/52
OMIM number: 602459
Comments closing date: 12/06/2026
Deafness, autosomal dominant 15/52 is a hereditary form of hearing loss caused by changes in the POU4F3 gene. This gene is important for maintaining the health and function of the sensory hair cells in the inner ear, which are essential for normal hearing. When the gene does not work as
expected, these hair cells gradually become damaged. This leads to progressive hearing loss.
Hearing is usually normal early in life, but it tends to decline slowly over time and both ears are
affected. Hearing loss related to POU4F3 is nonsyndromic, meaning it occurs on its own without any associated medical, physical or learning difficulties. Management typically includes regular hearing assessments and the use of hearing aids, or in some cases, cochlear implants. The age at which symptoms begin and the degree of hearing loss can vary widely between individuals, even within the same family.
