Anterior segment dysgenesis 2
OMIM number: 610256
Comments closing date: 09/10/2026
Anterior segment dysgenesis 2 (ASGD2; OMIM 610256) is a rare genetic disorder affecting the development of the front (anterior segment) of the eye, including the cornea, iris, lens and anterior chamber. The severity can vary, but affected individuals may have abnormalities such as congenital cataracts or absence of the lens, corneal abnormalities, abnormal iris development and glaucoma, potentially resulting in significant visual impairment or blindness. Inheritance: ASGD2 is typically autosomal recessive and is associated with pathogenic variants in the FOXE3 gene.
