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Human Leukocyte Antigen C (HLA-C2)

Human Leukocyte Antigen C (HLA-C2)

OMIM number: n/a

Comments closing date: 17/12/2020

In the uterus, women have certain cells that are
responsible for recognising a foreign element via
their killer cell immunoglobulin like receptors
(KIR) . This recognition activates the immune
system which is prepared to eliminate those
elements to protect the individual. Human
embryos have specific molecules, known as
human leukocyte antigen (HLA-C2), which are
able to trigger the mother’s immune system.
Several studies have revealed that specific KIRHLA-
C2 combinations could be responsible for
some scenarios of implantation failure and
miscarriage. It has been reported that such
combination leads to pre-eclampsia and foetal
restriction.

Review date: 19 November 2022