Review of scientific methods to avoid mitochondrial disease - 2014 update

On 27 February 2014 the government launched a consultation on the draft regulations on new techniques to prevent transmission of serious mitochondrial disease which closed on the 21 May 2014. Alongside this the HFEA was asked by government to reconvene its panel of experts to review the latest evidence on the safety and efficacy of the two mitochondrial donation techniques: pro-nuclear transfer (PNT) and maternal spindle transfer (MST). The HFEA submitted a report of the panel's findings to the Department of Health on 2 June 2014.

Membership of reconvened core panel:

  • Dr Andy Greenfield (Chair), Medical Research Council (MRC), Harwell and HFEA member
  • Professor Peter Braude, King’s College London
  • Dr Paul De Sousa, University of Edinburgh
  • Professor Robin Lovell-Badge, MRC National Institute for Medical Research
  • Professor Anneke Lucassen, University of Southampton and formerly Human Genetics Commission

Terms of reference

The group collated and summarised the current state of expert understanding on the safety and efficacy of maternal spindle transfer and pro-nuclear transfer in order to update their report of March 2013.


Page last updated: 22 July 2014