CARE, Nottingham
To examine concordance and mosaicism in oocytes and embryos
This project aims to evaluate accurately the chromosome status of oocytes and their subsequent embryos to make IVF more efficient.
Using technology that CARE Fertility helped to pioneer, we shall assess:
- a) the concordance of chromosome data between oocytes and each cell of its subsequent day 3 embryo
- b) we shall compare a single cell from a day 3 embryo to the cells of the corresponding day 5 blastocyst.
We wish to find the most biologically appropriate stage from which to obtain accurate data on chromosome copy number that will improve clinical outcome to patients undergoing IVF. To date, testing oocytes, day 3 embryos and the blastocyst provide concerns regarding concordance and mosaicism.
Do polar bodies, a single cell of a day 3 embryo, or blastocyst cells accurately predict the chromosome status of the embryo? Does a single cell of a day 3 embryo predict the chromosome status of all the cells of that embryo? These are questions that still need to be answered to secure a defined and robust clinical approach.
Deadline for comments to be submitted is 22 November.
Page last updated: 10 November 2011